MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Cilengitide TFA

CAS No. : 199807-35-7

MCE 站：Cilengitide TFA

产品活性：Cilengitide 是有效的，选择性的 α_vβ₃ 和 α_vβ₅ 受体整合素抑制剂，IC₅₀ 分别为 4 nM 和 79 nM。

研究领域：Cytoskeleton  |  Autophagy

作用靶点：Integrin  |  Autophagy

In Vitro: Cilengitide (EMD 121974) is the α_vβ₃ and α_vβ₅ integrin receptor antagonist. In cell adhesion studies assessing the human melanoma M21 or UCLA-P3 human lung carcinoma cell lines, Cilengitide inhibits integrin-mediated binding to vitronectin with IC₅₀s of 0.4 and 0.4 μM. In vitro treatment of Cilengitide, at a concentration greater than 1 ?M, shows concentration- and time-dependent cytotoxic effects .

In Vivo: In nude mice bearing M21-L melanoma tumors, Cilengitide dose i.p. at 10, 50, and 250 μg three times per week demonstrate inhibition of tumor growth with a reduction in both tumor volume (55%, 75%, and 89%, respectively) and tumor weight (23%, 38%, and 61%, respectively), when compared to controls. In the rat model studied, the systemic pharmacokinetics of i.p. Cilengitide are not affected by ILP with Cilengitide alone or ILP with Cilengitide plus Melphalan, TNF or both. Systemic Cilengitide levels reach around 20 ?g/mL (approximately 35 ?M) within 10 min of i.p. administration and continued to rise to approximately 40 ?g/mL (approximately 70 ?M) in the first hour. Thereafter Cilengitide levels in serum drop with an elimination half-life of 2.1 hr.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Macrocyclic Compound Library  |  Cytoskeleton Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Cilengitide  |  iRGD peptide  |  GLPG0187  |  MK-0429  |  E7820  |  ATN-161 trifluoroacetate salt  |  Cucurbitacin B  |  Leukadherin-1  |  RGD Trifluoroacetate  |  Arg-Gly-Asp-Ser  |  Eptifibatide  |  OSU-T315  |  A-205804  |  Cyclo(-RGDfK) TFA  |  RGD peptide (GRGDNP) (TFA)  |  Cyclo(RGDyK) trifluoroacetate  |  TR-14035  |  GRGDSP TFA  |  Tetrac  |  Tirofiban hydrochloride monohydrate  |  ILK-IN-3  |  BIO5192 hydrate  |  Natalizumab  |  Vedolizumab  |  α2β1 Integrin Ligand Peptide TFA  |  ICAM-1-IN-1  |  Zaurategrast ethyl ester  |  BIO5192  |  Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。