MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

IM156

CAS No. : 1422365-94-3

MCE 站：IM156

产品活性：IM156 (HL156A; HL271 acetate) 是二甲双胍 (HY-B0627) 的化学衍生物，是一种强效的，具有口服活性的 AMPK 激活剂。IM156 在动物模型中可缓解与年龄相关的认知障碍。IM156 是一种有效的氧化磷酸化 (OXPHOS) 抑制剂，可用于实体肿瘤的研究。

研究领域：Epigenetics  |  PI3K/Akt/mTOR

作用靶点：AMPK

In Vitro: IM156 (0.31-10 μM) phosphorylates AMPKα1 Thr172 in a dose- and time-dependent manner in NIH3T3 mouse fibroblast cells.
IM156 does not affect the expression of key factors involved in glucose homeostasis such as glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1).

In Vivo: IM156 does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity.
IM156 (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety.
IM156 significantly attenuates the aging-induced decline in novel object recognition memory and spatial working memory.
IM156 significantly increases AMPK activation in the hippocampus of aged mice.

相关产品：Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Diabetes Related Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Doxorubicin hydrochloride  |  Metformin hydrochloride  |  Dorsomorphin  |  AICAR  |  A-769662  |  GSK-690693  |  STO-609  |  Phenformin hydrochloride  |  [6]-Gingerol  |  WZ4003  |  Palmitelaidic Acid  |  Urolithin B  |  GSK621  |  Flufenamic acid  |  Chitosan oligosaccharide  |  Amarogentin  |  7-Methoxyisoflavone  |  Buformin hydrochloride  |  Danthron  |  Ginkgolide C  |  ZLN024 hydrochloride  |  Ampki  |  EB-3D  |  Demethyleneberberine  |  Gomisin J  |  Platycodin D  |  Methyl cinnamate

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。