当前位置: 易推广 > 生物试剂/抗体/细胞 > 生化试剂 > 其他 > MedChemExpress > 产品展示 > MCE信号通路 > NF-κB 信号通路 > GS143
GS143
企业档案
会员类型:会员
已获得易推广信誉 等级评定
(0 -40)基础信誉积累,可浏览访问
(41-90)良好信誉积累,可接洽商谈
(91+ )优质信誉积累,可持续信赖
易推广会员:8年
最后认证时间:
注册号: 【已认证】
法人代表: 【已认证】
企业类型:生产商 【已认证】
注册资金:人民币万 【已认证】
产品数:91228
参观次数:11433370
联系我们
MedChemExpress
电话:021-58955995
联系人:客服部 (请说明是在易推广看到的!谢谢)
手机:13611715263
邮编:201203
邮箱:sales@medchemexpress.cn
地址:上海上海
详细内容
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
GS143
CAS No. : 916232-21-8
MCE 站:GS143
产品活性:GS143 是一种选择性的 IκBα 泛素化抑制剂,对于 SCFβTrCP1 介导的 IκBα 泛素化作用的 IC50 为 5.2 μM。GS143 抑制靶基因的 NF-κB 活化和转录,并且不抑制蛋白酶体的活性,并具有抗哮喘作用。
研究领域:NF-κB | Metabolic Enzyme/Protease
作用靶点:IKK | E1/E2/E3 Enzyme | NF-κB
In Vitro: GS143 (10 μM or 20 μM) inhibits antigen-induced differentiation of Th2 cells but not of Th1 cells in vitro. The IL-4 pro?duc?tion in Th2-polar?iz?ing con?di?tion is mark?edly sup?pressed by GS143 in a dose-depen?dent man?ner.
GS143 suppresses the transcription of TNFα-induced NF-κB with a mean IC50 value of 10.5 μM. GS143 also inhibits TNFα-induced expression of ICAM-1 in HT-29 colon cancer cells with an IC50 value of 6.1 μM. The production levels of TNFα and IL-1β in LPS-activated THP-1 cells are inhibited with IC50 values of 5.3 μM and 2.1 μM, respectively. GS143 does not inhibit p53 and β-catenin.
In Vivo: GS143 (16-32 μg/body; intranasal administration; once; BALB/c mice) treatment suppresses antigen-induced NF-κB activation in the lung of sensitized mice. GS143 treatment also inhibits antigen-induced eosinophil and lymphocyte recruitment into the airways and the expression of Th2 cytokines and eotaxin in the airways.
相关产品:Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Anti-Aging Compound Library | Antioxidants Compound Library | Differentiation Inducing Compound Library | Oxygen Sensing Compound Library | Ubiquitination Compound Library | Pyroptosis Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Bortezomib | BAY 11-7082 | Resveratrol | Pyrrolidinedithiocarbamate ammonium | Nutlin-3a | JSH-23 | BX795 | Shikonin | Triptolide | Rocaglamide | Dihydroartemisinin | Amlexanox | Baicalin | BAY 11-7085 | Sulfasalazine | Betulinic acid | SN50 | TPCA-1 | Parthenolide | PYR-41 | MRT67307 | BI8622 | (-)-DHMEQ | 5-Aminosalicylic Acid | Caffeic acid phenethyl ester | IMD-0354 | Neferine | Ginkgolic Acid | Tomatidine
品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物;
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
• 专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。
热门标签:gs-143