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Ropivacaine

CAS No. : 84057-95-4

MCE 站：Ropivacaine

产品活性：Ropivacaine 是一种有效的钠通道 (sodium channel) 阻断剂，可以作为局部麻醉试剂。Ropivacaine 通过可逆地抑制钠离子内流 (sodium ion influx) 从而引起神经纤维脉冲传导阻滞。Ropivacaine 也是一种 K_2P (双孔钾通道) TREK-1 的抑制剂，在 COS-7 细胞膜上的 IC₅₀ 值为 402.7 μM。Ropivacaine 用于局部麻醉和神经性疼痛的缓解的相关研究。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Sodium Channel  |  Potassium Channel

In Vivo: Epidural administration of Ropivacaine effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury.
Ropivacaine inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC).
Ropivacaine prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats.
Ropivacaine inhibits pressure-induced NO production as evidenced by decreased lung nitro-tyrosine content when compared to hypertensive lungs.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  Bioactive Compound Library Plus  |  Membrane Transporter/Ion Channel Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  NMPA-Approved Drug Library  |  FDA Approved & Pharmacopeial Drug Library  |  Neuroprotective Compound Library  |  Nigericin sodium salt  |  BAPTA-AM  |  EIPA  |  Amiloride hydrochloride  |  Monensin sodium salt  |  Rosuvastatin Calcium  |  SKF-96365 hydrochloride  |  Glibenclamide  |  Carbamazepine  |  SCH-23390 hydrochloride  |  Tetrandrine  |  Amiodarone hydrochloride  |  5-(N,N-Hexamethylene)-amiloride  |  Riluzole  |  TRAM-34  |  Ifenprodil tartrate  |  Minoxidil  |  Diazoxide  |  20(S)-Ginsenoside Rg3  |  Senicapoc  |  Tannic acid  |  DCPIB  |  Lidocaine  |  Amitriptyline hydrochloride  |  Astemizole  |  Ketanserin  |  Quinine  |  Cariporide  |  E-4031  |  Terfenadine

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