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Amodiaquine dihydrochloride

CAS No. : 69-44-3

MCE 站：Amodiaquine dihydrochloride

产品活性：Amodiaquine dihydrochloride (Amodiaquin dihydrochloride) 是一种4-氨基喹啉类抗疟剂，是一种有效的具有口服活性的组胺 N-甲基转移酶 (histamine N-methyltransferase) 抑制剂，K_i 值为 18.6 nM。Amodiaquine dihydrochloride 也是一种 Nurr1 激动剂，可特异性结合 Nurr1 的配体结合域，EC₅₀ 为 ~20 μM。抗炎作用。

研究领域：Anti-infection  |  Epigenetics

作用靶点：Parasite  |  Histone Methyltransferase

In Vitro: Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH⁺ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells.

In Vivo: Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Epigenetics Compound Library  |  Immunology/Inflammation Compound Library  |  FDA-Approved Drug Library  |  Histone Modification Research Compound Library  |  Drug Repurposing Compound Library  |  Reprogramming Compound Library  |  NMPA-Approved Drug Library  |  Pyroptosis Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Neuroprotective Compound Library  |  Anti-Blood Cancer Compound Library  |  Chloroquine  |  Hydroxychloroquine sulfate  |  Ivermectin  |  Kaempferol  |  Metronidazole  |  Dihydroartemisinin  |  Niclosamide  |  3-Deazaneplanocin A hydrochloride  |  Suramin sodium salt  |  Artesunate  |  Artemisinin  |  Chaetocin  |  UNC0642  |  UNC1999  |  Quinidine  |  MS023  |  BIX-01294  |  Halofugi  |  Miransertib  |  EPZ020411 hydrochloride  |  MM-102 TFA  |  SGC0946  |  Mefloquine hydrochloride  |  Quinacrine dihydrochloride  |  Sanguinarine chloride  |  A-366  |  Amodiaquine dihydrochloride dihydrate  |  Ascomycin  |  CM-272

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