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Adenosine dialdehyde
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Adenosine dialdehyde
CAS No. : 34240-05-6
MCE 站:Adenosine dialdehyde
产品活性:Adenosine Dialdehyde 是嘌呤核苷的类似物,是 S-腺苷同型半胱氨酸水解酶 (SAHH) 的不可逆抑制剂 (Ki=3.3 nM)。Adenosine Dialdehyde 具有抗肿瘤活性,可用于肿瘤研究。
作用靶点:Nucleoside Antimetabolite/Analog
In Vitro: Adenosine dialdehyde suppresses MNB cell replication in tissue culture with concentra tions of 1.5 μM with producing 50% inhibition.
In Vivo: Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals.Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice.Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity.
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热门标签:adenosine