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NNMTi

CAS No. : 42464-96-0

MCE 站：NNMTi

产品活性：NNMTi 是一种有效的烟酰胺 N -甲基转移酶 (NNMT) 的抑制剂 (IC₅₀=1.2 μM)，可选择性地结合 NNMT 底物结合位点残基。NNMTi 能促进体外成肌细胞分化，增强老年小鼠肌肉干细胞融合和再生能力。

研究领域：Others

作用靶点：Others

In Vitro: NNMTi (10-30 ?M; 96 hours) produces a concentration-related increase in myoblast differentiation on C2C12 myoblast differentiation. 30 ?M NNMTi results in 18% MHC-positive myotube nuclei, representing a 45% increase in the extent of myoblast differentiation compared to untreated differentiating myoblasts (12% MHC-positive myotube nuclei).

In Vivo: NNMTi (subcutaneous (SC) injection; 5 mg/kg and 10 mg/kg; 2 weeks (1 week pre-injury and 1 week post-injury)) has an effect on muscle regeneration after injury, it results in 60% and 75% higher incidence of proliferating/active muSCs at 5 mg/kg and 10 mg/kg, respectively. The relative numbers of fibers with an EdU⁺?myonucleus increased 40% and 48% with NNMTi treatment at 5 mg/kg and 10 mg/kg, respectively. The odds ratio of fused myonuclei for control are 0.58 and 0.53 times the odds at the low and high NNMTi dose, respectively.
NNMTi (subcutaneous injection; 10 mg/kg; 1 week) produces no systemic toxicity in mice, the levels of the glucose, cholesterol, plasma proteins, and electrolytes between control and NNMTi-treated samples show no difference in mice. 1-week post-injury daily repeat-dosing of NNMTi is well tolerated with no untoward systemic toxicity or behavioral implications in aged mice.

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