MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

FGFR1/DDR2 inhibitor 1

CAS No. : 2308497-58-5

MCE 站：FGFR1/DDR2 inhibitor 1

产品活性：FGFR1/DDR2 inhibitor 1 是具有口服活性的成纤维细胞生长因子受体 1 (FGFR1) 和盘状蛋白域受体 2 (DDR2) 的抑制剂，其对 FGFR1 和 DDR2 的IC₅₀ 值分别为 31.1 nM、3.2 nM。具有抗肿瘤活性。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：FGFR  |  Discoidin Domain Receptor

In Vitro: FGFR1/DDR2 inhibitor 1 (compound 11k) (25-200 μM; 2 hours) shows significant inhibition of FGFR2 phosphorylation in a dose-dependent manner in SNU16 cells. FGFR1/DDR2 inhibitor 1 shows (60-250 μM; 2 hours) significant inhibition of DDR2 phosphorylation in a dose-dependent manner in H2286 cells.
FGFR1/DDR2 inhibitor 1 significantly inhibits the proliferation of FGFR-driven cancer cell lines with IC₅₀s of 108.4, 93.4, 31.8 and 306.6 nM against KG-1, SNU-16, NCI-H716 and UMUC14 respectively. FGFR1/DDR2 inhibitor 1 demonstrates substantially activity against the DDR2-driven cancer cell line NCI-H2286 (93.0 nM).

In Vivo: FGFR1/DDR2 inhibitor 1 (10-20 mg/kg; p.o.; once daily for 7 days) has profound anti-tumor efficacy in NCI-H1581 tumor model.
SCID mice bearing NCI-H2286 tumors were randomized and treated with FGFR1/DDR2 inhibitor 1 at doses of 10 mg/kg for 10 consecutive days. FGFR1/DDR2 inhibitor 1 could suppress tumor growth with tumor growth inhibition rates (TGI) of 82.8%.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  Anti-Cancer Compound Library  |  Reprogramming Compound Library  |  Orally Active Compound Library  |  Anti-Lung Cancer Compound Library  |  SU 5402  |  Heparan Sulfate  |  PD173074  |  Formotin  |  Gandotinib  |  KW-2449  |  Ferulic acid  |  WRG-28  |  PD-166866  |  DDR1-IN-1  |  CP-547632  |  PP58  |  VU6015929  |  SUN11602  |  R1530  |  2,5-Dihydroxybenzoic acid  |  Tyrosine kinase-IN-1  |  DDR Inhibitor  |  PD-161570  |  ARQ 069  |  PD-089828  |  SM1-71  |  SU4984  |  DDR-TRK-1

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。