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SAR502250

CAS No. : 503860-57-9

MCE 站：SAR502250

产品活性：SAR502250 是一种有效的，选择性的，ATP竞争性，具有口服活性和可透过血脑屏障的 GSK3 抑制剂，对人 GSK-3β 的 IC₅₀ 值为 12 nM。SAR502250 显示出抗抑郁样活性。SAR502250 可用于研究阿尔茨海默症 (AD)。

研究领域：PI3K/Akt/mTOR  |  Stem Cell/Wnt

作用靶点：GSK-3

In Vitro: SAR502250 (0.01-1 μM; 36 h) attenuates the Aβ_25-35-induced cell death in rat embryonic hippocampal neurons.

In Vivo: SAR502250 (1-100 mg/kg; a single p.o,) attenuates tau hyperphosphorylation in the cortex and spinal cord of transgenic mice expressing P301L tau.
SAR502250 (10-30 mg/kg; p.o. once daily for 7 weeks) improves the cognitive deficit in transgenic APP(SW)/Tau(VLW) mice after infusion of Aβ_25-35.
SAR502250 (10-30?mg/kg; a single p.o.) significantly increases the percentage of lever-presses in the inter-response time (IRT) bin (49-96?s), with a significant augmentation of the percentage of reinforced responses.
SAR502250 (30?mg/kg; i.p. once daily for 28 d) ameliorates chronic stress-induced degradation of the physical state of the mice coat.
SAR502250 (10-60 mg/kg; a single p.o.) decreases hyperactivity produced by psychostimulantsin mice.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Stem Cell Signaling Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  CNS-Penetrant Compound Library  |  Anti-Aging Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Orally Active Compound Library  |  Anti-Alzheimer’s Disease Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  CHIR-99021  |  SB 216763  |  AR-A014418  |  TDZD-8  |  Kenpaullone  |  GSK 3 Inhibitor IX  |  Cromolyn sodium  |  R547  |  SB 415286  |  IM-12  |  Indirubin-3'-monoxime  |  1-Azakenpaullone  |  AZD2858  |  BIO-acetoxime  |  CP21R7  |  Bikinin  |  GNF4877  |  GSK-3β inhibitor 1  |  hSMG-1 inhibitor 11j  |  TCS 21311  |  BIP-135  |  5-Iodo-indirubin-3'-monoxime  |  Alsterpaullone  |  GSK-3 inhibitor 1  |  GSK-3β inhibitor 2  |  Manzamine A hydrochloride  |  2B-(SP)

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