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Seralutinib

CAS No. : 1619931-27-9

MCE 站：Seralutinib

产品活性：Seralutinib (GB002) 是一个可吸入的 PDGFRα 和 PDGFRβ 激酶抑制剂。Seralutinib (GB002) 可用于肺动脉高压的研究。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：PDGFR

In Vivo: Seralutinib (GB002) (two-week treatment, delivered by inhalation) significantly reduces right ventricular systolic pressure and mean pulmonary artery pressure. Hemodynamic changes are accompanied by reduced pulmonary arteriole muscularization and restoration of BMPR2 protein expression in the lung lobes in Seralutinib (GB002)-treated animals. Seralutinib (GB002) is well tolerated.
GB002-mediated inhibition of lung PDGFRα/β phosphorylation in healthy Sprague Dawley rats immediately post inhalation.
GB002 dose- and time-dependently induces lung BMPR2 protein expression.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  Clinical Compound Library  |  Drug Repurposing Compound Library  |  Reprogramming Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Sunitinib  |  Imatinib  |  SU 5402  |  Cediranib  |  Ki20227  |  SU14813  |  PP121  |  PP58  |  Sennoside B  |  AG 1295  |  Methylnissolin  |  SU16f  |  Trapidil  |  Tyrosine kinase-IN-1  |  Tyrphostin AG1296  |  Tyrphostin AG1433  |  NVP-ACC789  |  PD-161570  |  SU4312  |  Hypothemycin  |  Imatinib D4  |  Imatinib D8  |  Multi-kinase inhibitor 1  |  N-(p-Coumaroyl) Serotonin  |  PD-089828  |  SU4984

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