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Cardiogenol C

CAS No. : 671225-39-1

MCE 站：Cardiogenol C

产品活性：Cardiogenol C 是一种有效的细胞渗透性嘧啶诱导剂，可促使 ESCs 分化为心肌细胞 (ESCs differentiation into cardiomyocytes) (EC₅₀=100 nM)。Cardiogenol C 还可以在有限的可塑性范围内对已经沿袭的祖细胞类型产生心肌病。Cardiogenol C 是一种有效的心肌发生剂。

研究领域：Stem Cell/Wnt

作用靶点：β-catenin  |  Wnt

In Vitro: Cardiogenol C (1 μM; 7 days) has a cardiomyogenic effect on P19 cells, it significantly increases atrial natriuretic factor (ANF,?nppa) in P19 cells when it compares to untreated control cells.
Cardiogenol C (0.01-100 μM; 7 days) significantly increases ANF expression. In addition, another frequently used cardiac marker gene (NKX2-5) is also significantly increased by this small molecule in C2C12 cells.
Cardiogenol C (0.001-100 μM; 7 days) increases cardiac Nav1.5 sodium channel protein expression as dose-dependent manner in C2C12 cells.
Cardiogenol C (0.01-100 μM; 7 days) does not effect cell growth even at 10 μM. In addition, Cardiogenol C either solves in water or DMSO generates a similar effect. The highest concentration, 100 μM has significant cellular toxicity on C2C12 cells.

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