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DHODH-IN-14

CAS No. : 1364791-93-4

MCE 站：DHODH-IN-14

产品活性：DHODH-IN-14 (Compound 7l) 是一种 A771726 的 hydroxyfurazan 类似物。DHODH-IN-14 是一种二氢乳清酸脱氢酶 (DHODH) 抑制剂，对大鼠肝脏 DHODH 的 IC₅₀ 为 0.49 μM。DHODH-IN-14 可用于类风湿关节炎。

研究领域：Metabolic Enzyme/Protease  |  Cell Cycle/DNA Damage

作用靶点：Dihydroorotate Dehydrogenase  |  DNA/RNA Synthesis

In Vitro: DHODH-IN-14 (Compound 7l) is a hydroxyfurazan analog of A771726, in which the biphenyl scaffold with fluoro substituents. Moving to derivatives DHODH-IN-14, no major differences were observed among the poses obtained on 1UUO and 1D3G; in both cases DHODH-IN-14 is found to bind in a BQN-like fashion, namely with the deprotonated hydroxyfurazan moiety facing Arg136, thus effectively mimicking the carboxyl group of BQN and related compounds. While on 1D3G and 1UUO the hydroxyfurazan is in no case found to interact with Tyr356 in a Leflunomide-like fashion, a significant fraction of such poses is found when 2BXV is used as the docking target.

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