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Mito-LND

CAS No. : 2361564-49-8

MCE 站：Mito-LND

产品活性：Mito-LND (Mito-Lonidamine) 是一种具有口服活性的且靶向线粒体的氧化磷酸化 (oxidative phosphorylation (OXPHOS)) 抑制剂。Mito-LND 抑制线粒体生物能，刺激活性氧 (reactive oxygen species) 的形成，并诱导肺癌细胞自噬细胞死亡。

研究领域：Metabolic Enzyme/Protease  |  NF-κB  |  Immunology/Inflammation  |  Autophagy

作用靶点：Mitochondrial Metabolism  |  Reactive Oxygen Species  |  Autophagy

In Vitro: Mito-LND blocks lung cancer growth, migration, and invasion. Mito-LND inhibits cell growth of H2030BrM3 and A549 cells with IC₅₀ values of 0.74 ?M and 0.69??M, respectively.
Mito-LND inhibits mitochondrial complex I and II activities with IC₅₀ values of 1.2 ?M and 2.4??M, respectively in H2030BrM3 cells.
Mito-LND (1??M) increases ROS generation in H2030BrM3 lung cancer cells. Mito-LND potently induces mitochondrial ROS generation in H2030BrM3 lung cancer cells.
Mito-LND (2??M) decreases the levels of phosphorylated AKT. Mito-LND also decreases the phosphorylation of P70S6K and other energy-sensing proteins in both the parental and metastatic lung cancer cell lines, indicating that Mito-LND specifically downregulates mTOR signaling.

In Vivo: Mito-LND (7.5??mol/kg; oral gavage; 5 days per week; for 3 consecutive weeks) treatment markedly enhanced potency against both lung cancer progression and metastasis.
Mito-LND also decreases the rate of growth of A549 tumor xenografts.
Mito-LND treatment shows a marked decrease in lung cancer brain metastasis in NOD/SCID mice bearing H2030BrM3 cells.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Pyroptosis Compound Library  |  Orally Active Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Lung Cancer Compound Library  |  Acetylcysteine  |  H2DCFDA  |  CCCP  |  Rote  |  Quercetin  |  Mitoqui mesylate  |  FCCP  |  (-)-Epigallocatechin Gallate  |  L-Ascorbic acid  |  Diphenyleneiodonium chloride  |  Mito-TEMPO  |  UK-5099  |  GSK2795039  |  Trolox  |  L-Glutathione reduced  |  Dimethyl fumarate  |  Berberine chloride  |  Zinc Protoporphyrin  |  Sodium dichloroacetate  |  Lycopene  |  2-Methoxyestradiol  |  TPEN  |  Urolithin A  |  α-Vitamin E  |  Tempol  |  Piperlongumine  |  Coenzyme Q10  |  Asiaticoside  |  Lonidamine  |  N-Acetylcysteine amide

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