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Pirarubicin Hydrochloride
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Pirarubicin Hydrochloride
CAS No. : 95343-20-7
MCE 站:Pirarubicin Hydrochloride
产品活性:Pirarubicin Hydrochloride (THP Hydrochloride) 是一种蒽环类抗生素,为拓扑异构酶 II (topoisomerase II) 的抑制剂,可用于各种癌症尤其是实体瘤的研究。
研究领域:Cell Cycle/DNA Damage | Autophagy | Anti-infection
作用靶点:Topoisomerase | Autophagy | Bacterial | Antibiotic
In Vitro: Pirarubicin is a topoisomerase II inhibitor. Pirarubicin shows inhibitory activities against M5076 and Ehrlich cells, with IC50s of 0.366 and 0.078 μM, respectively. The cytotoxicity of Pirarubicin toward M5076 cells is lower than toward Ehrlich cells, and this is due to the much lower expression of topoisomerase II in M5076 cells than in Ehrlich cells. Pirarubicin (2.5, 5, 10 μg/mL) significantly induces autophagy in a dose dependent manner in bladder cancer (T24, EJ, 5637, J82 and UM-UC-3) cells. Furthmore, Pirarubicin (5 μg/mL) induces apoptosis through inhibition of mTOR/p70S6K/4E-BP1 in bladder cancer cells, and this effect is enhanced by inhibition of autophagy.
In Vivo: Pirarubicin (18 mg/kg, i.v.) significantly elevates serum level of BNP, CK-MB, CTnT, LDH, and MDA compared with those in the control group in acute cardiac toxicity rats. Pirarubicin also lowers heart rate, and depresses R-wave voltage, and prolongation of QT intervals in the acute cardiac toxicity model.
相关产品:Natural Product Like Compound Library | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Anti-Infection Compound Library | Cell Cycle/DNA Damage Compound Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Antibacterial Compound Library | Anti-COVID-19 Compound Library | NMPA-Approved Drug Library | FDA Approved & Pharmacopeial Drug Library | Antibiotics Library | Anti-Blood Cancer Compound Library | Rapamycin | Doxorubicin hydrochloride | Bafilomycin A1 | Puromycin dihydrochloride | Cycloheximide | Chloroquine | Staurosporine | Dexamethasone | Doxycycline (hyclate) | Actinomycin D | Cyclosporin A | G-418 disulfate | 5-Azacytidine | Etoposide | Mitomycin C | CCCP | Nigericin sodium salt | Brefeldin A | Wortmannin | Resveratrol | Tunicamycin | Bleomycin sulfate | Hygromycin B | Tacrolimus | Ionomycin | Vancomycin hydrochloride | Streptozocin | Tanespimycin | Irinotecan
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热门标签:THP Hydrochloride