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THZ2

CAS No. : 1604810-84-5

MCE 站：THZ2

产品活性：THZ2 是有效，选择性的 CDK7 抑制剂，IC₅₀ 值为 13.9 nM。

研究领域：Cell Cycle/DNA Damage

作用靶点：CDK

In Vitro: THZ2 selectively targets CDK7 and potently inhibits the growth of triple-negative but not ER/PR⁺ breast cancer cells. THZ2 at low nanomolar doses also efficiently suppresses the clonogenic growth of TNBC cells with IC₅₀ of appr 10 nM. THZ2 induces apoptotic cell death in triple-negative but not ER/PR⁺ breast cancer cells or normal human cells.

In Vivo: THZ2 (10 mg/Kg) markedly reduces the growth rate of tumors in mice and demonstrates an anti-tumor activity. Compared to vehicle-treated tumors, tumor tissues isolated from mice treated with THZ2 has reduced proliferation and increased apoptosis, as indicated by immunostaining against Ki67 and cleaved Caspase 3 respectively. THZ2 in NOD-SCID mice leads to reduced body weight, suggesting that THZ2 mayt be less well-tolerated in this particular mouse strain.

相关产品：Covalent Screening Library Plus  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Covalent Screening Library  |  Anti-Breast Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Ro-3306  |  Seliciclib  |  Flavopiridol  |  NVP-2  |  SNS-032  |  AZD-5438  |  Kenpaullone  |  GSK 3 Inhibitor IX  |  AUZ 454  |  XL413 hydrochloride  |  CGP60474  |  Wogonin  |  CVT-313  |  NG 52  |  BMS-265246  |  (R)-CR8 trihydrochloride  |  R547  |  PHA-767491 hydrochloride  |  CDK12-IN-3  |  KH-CB19  |  CDK2-IN-4  |  Purvalanol A  |  Cucurbitacin E  |  THZ1-R  |  FMF-04-159-2  |  LY2857785  |  CP-10  |  ML167

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