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Pyrantel pamoate

CAS No. : 22204-24-6

MCE 站：Pyrantel pamoate

产品活性：Pyrantel pamoate (Pyrantel embonate)，一种四氢嘧啶光谱驱虫剂，是烟碱乙酰胆碱受体 (nAChR) 激动剂。Pyrantel pamoate 可引起寄生虫的痉挛性肌肉麻痹。Pyrantel pamoate 可用于胃肠道线虫感染的研究。

研究领域：Anti-infection

作用靶点：Parasite  |  Antibiotic

In Vitro: Pyrantel induces Ascaris suum muscle contraction, with a pEC₅₀ of 7.24.
Pyrantel produces spastic paralysis of the nematode by selectively gating acetylcholine receptor ion-channels on nerve and muscle.
Pyrantel (72 h) inhibits the survival of Ancylostoma ceylanicum, Necator americanus and Trichuris muris on the third-stage larvae (IC₅₀s=90.9, 2.0, and 95.5 ?g/mL, respectively) and adult worms (IC₅₀s=>100, 7.6, and 34.1 ?g/mL, respectively).

In Vivo: Pyrantel (10 mg/kg; a single p.o.) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%.

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