MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

MDL 105519

CAS No. : 161230-88-2

MCE 站：MDL 105519

产品活性：MDL 105519是有效和选择性的甘氨酸与 NMDA 受体结合的拮抗剂。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：iGluR

In Vitro: MDL 105519 is a potent and selective ligand for the glycine recognition site that completely inhibit the binding of [³H]glycine to rat brain membranes with a K_i value of 10.9 nM. MDL 105519 is approximately 10,000-fold selective for the glycine recognition site relative to the other receptor types investigated. MDL 105519 inhibits NMDA-dependent responses, such as elevations of [³H]TCP binding in brain membranes, cyclic GMP accumulation in brain slices, and alterations in cytosolic Ca²⁺ and Na⁺-Ca²⁺ currents in cultured neurons. Inhibition is non-competitive with respect to NMDA and could be nullified with D-serine.

In Vivo: MDL 105519 is an NMDA receptor antagonist in vivo. Intravenously administration of MDL 105519 prevents harmaline-stimulated increases in cerebellar cyclic GMP content, providing biochemical evidence of NMDA receptor antagonism in vivo. This antagonism is associated with anticonvulsant activity in genetically based, chemically induced, and electrically mediated seizure models. Anxiolytic activity is observed in the rat separation-induced vocalization model, but muscle-relaxant activity is apparent at lower doses. Higher doses impair rotorod performance, but are without effect on mesolimbic dopamine turnover or prepulse inhibition of the startle reflex.

相关产品：Bioactive Compound Library Plus  |  Membrane Transporter/Ion Channel Compound Library  |  Neuronal Signaling Compound Library  |  Neurotransmitter Receptor Compound Library  |  Anti-Alzheimer’s Disease Compound Library  |  Neuroprotective Compound Library  |  Dizocilpine maleate  |  D-AP5  |  NMDA  |  CNQX  |  NBQX  |  Ifenprodil tartrate  |  L-Phenylalanine  |  Ibotenic acid  |  Kynurenic acid  |  Memantine hydrochloride  |  L-Glutamic acid monosodium salt  |  Quinolinic acid  |  Glycine  |  Ro 25-6981 Maleate  |  DNQX  |  D-Cycloserine  |  PEAQX tetrasodium hydrate  |  Transcrocetin  |  CX546  |  Traxoprodil  |  ZL006  |  Flupirtine Maleate  |  Cycloleucine  |  MDL-29951  |  Topiramate  |  (-)-Huperzine A  |  (S)-Willardiine  |  24-Hydroxycholesterol  |  Philanthotoxin 74 dihydrochloride

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。