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ML228

CAS No. : 1357171-62-0

MCE 站：ML228

产品活性：ML228 (CID-46742353) 是一种有效的 HIF 信号通路激活剂，EC₅₀ 为 1 μM。ML228 可激活 HIF 以及下游 EGFR。

研究领域：Metabolic Enzyme/Protease

作用靶点：HIF/HIF Prolyl-Hydroxylase

In Vitro: ML228 (CID-46742353) represents a novel chemotype available to the research community for the study of HIF activation and its therapeutic potential. Not only is the compound substantially different in structure from known HIF activators, ML228 lacks the acidic functional group almost universally present in PHD inhibitors, which may be important for certain disease applications.

In Vivo: ML228 (injection; 1 ?g/kg; 7 days) treatments following spinal cord injury (SCI) improves the local hypoxic ischemia environment, reduce SCI secondary injury and promote the recovery of neurological function.

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