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MHY1485
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MHY1485
CAS No. : 326914-06-1
MCE 站:MHY1485
产品活性:MHY1485 是一种有效的细胞渗透性 mTOR 激活剂,靶向 mTOR 的 ATP 结构域。MHY 1485 通过抑制自噬体和溶酶体之间的融合来抑制自噬 (autophagy)。
研究领域:PI3K/Akt/mTOR | Autophagy
In Vitro: MHY1485 (10 μM; 4 hours) shows that GCDC-induced autophagic activity is inhibited by upregulating p-mTOR expression and downregulating LC3 and p62 expression in HCC cells.MHY1485 (5 μM; 6 hours) increases the LC3II/LC3I ratio in a dose and time-dependently manner due to presumably inhibited LC3II degradation in rat liver Ac2F cells.MHY1485 (0.5-2 μM; 6 hours) increases the phosphorylation of mTOR at ser2448 and upregulates the level of phosphorylation of 4E-BP1 in a dose-dependently manner in Ac2F cells.
In Vivo: MHY1485 (intraperitoneal injection; 10?mg/kg, 2 days) blocks the autophagy signaling induced by follicle-stimulating hormone (FSH). It increases p-mTOR and p-S6K1 expression levels, whereas LC3 expression shows no marked change compared to that in the control group.
相关产品:Bioactive Compound Library Plus | Kinase Inhibitor Library | PI3K/Akt/mTOR Compound Library | Stem Cell Signaling Compound Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Antioxidants Compound Library | Oxygen Sensing Compound Library | Glycolysis Compound Library | Cytoskeleton Compound Library | Glutamine Metabolism Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Rapamycin | Everolimus | 3BDO | Temsirolimus | Salidroside | Torkinib | PI-103 | D-α-Hydroxyglutaric acid disodium | L-Leucine | Dihydromyricetin | PKI-402 | Polyphyllin I | Rheb inhibitor NR1 | GSK1059615 | GNE-317 | PP121 | WYE-354 | Cyclovirobuxine D | HDACs/mTOR Inhibitor 1 | XL388 | ETP-46464 | Palomid 529 | WAY-600 | Arnicolide D | (+)-Usnic acid | hSMG-1 inhibitor 11j | mTOR inhibitor-1 | TMBIM6 antagonist-1 | Hederacolchiside A1 | NSC781406
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