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AEBSF hydrochloride

CAS No. : 30827-99-7

MCE 站：AEBSF hydrochloride

产品活性：AEBSF hydrochloride 是丝氨酸蛋白酶 的不可逆抑制剂，可抑制例如胰凝乳蛋白酶，激肽释放酶，纤溶酶，凝血酶和胰蛋白酶。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：Thrombin  |  Influenza Virus

In Vitro: AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern.

In Vivo: AEBSF (76.8 mg/kg daily, i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection.?AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model.

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