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Estramustine phosphate sodium

CAS No. : 52205-73-9

MCE 站：Estramustine phosphate sodium

产品活性：Estramustine phosphate sodium，一种雌二醇类似物，是一种具有口服活性抗微管化疗剂。Estramustine phosphate sodium 通过与微管相关蛋白 (MAP) 和/或微管蛋白结合而使微管解聚。Estramustine phosphate sodium 可诱导前列腺癌细胞凋亡 (apoptosis)，并可用于前列腺癌的研究。

研究领域：Cell Cycle/DNA Damage  |  Cytoskeleton  |  Apoptosis

作用靶点：Microtubule/Tubulin  |  Apoptosis

In Vitro: Estramustine phosphate sodium (1 ?g/mL) treatment suppressed PC3 cell growth.
Estramustine phosphate sodium (2 ?g/mL) treatment significantly elevates phosphatidylserine eversion amount on PC3 cells. Estramustine phosphate sodium induces PC3 cell apoptosis.
Estramustine phosphate sodium (2 ?g/mL) treatment decreases MiR-31 level. Estramustine phosphate odium induces s prostate cancer cell line PC3 apoptosis through reducing miR-31.
Estramustine phosphate sodium, a unique antitumour agent, is selectively taken up by prostate cells and exerts antineoplastic effects by interfering with microtubule of dynamics and by reducing plasma levels of testosterone.
Estrone and estradiol, products of the metabolism of Estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels similar to those achieved after surgical castration.

In Vivo: Estramustine phosphate sodium (4-12 mg/kg; intraperitoneal injection; daily; for 2 weeks) inhibits PAC120 tumor growth 53% by day 35.

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