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CDDO-Im

CAS No. : 443104-02-7

MCE 站：CDDO-Im

产品活性：CDDO-Im (RTA-403) 是 Nrf2 和 PPAR 的活化剂，对 PPARα 和 PPARγ 的 K_i 分别为232 nM 和 344 nM。

研究领域：NF-κB  |  Cell Cycle/DNA Damage  |  Apoptosis

作用靶点：Keap1-Nrf2  |  PPAR  |  Ferroptosis

In Vitro: CDDO-Im is highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines (IC₅₀ approximately 10-30 nM). In U937 leukemia cells, CDDO-Im also induces monocytic differentiation as measured by increased cell surface expression of CD11b and CD36. Treatment with CDDO-Im elevates protein levels of Nrf2, a transcription factor previously shown to bind ARE sequences, and increases expression of a number of antioxidant and detoxification genes regulated by Nrf2. CDDO-Im is one of the most potent synthetic triterpenoids shown to induce growth inhibition and apoptosis in various human cancer cells, including multiple myeloma, lung, pancreas and breast cancer. CDDO-Im treatment markedly induces cell cycle arrest at G2/M-phase and apoptosis in the triple-negative breast cancer cell lines, SUM159 and MDA-MB-231. The CD24?/EpCAM+ cells in SUM159 tumorspheres are significantly inhibited by CDDO-Im treatment. CDDO-Im also significantly decreases sphere forming efficiency and tumorsphere size in both primary and secondary sphere cultures.

In Vivo: CDDO-Im is a potent inhibitor of de novo inducible nitric oxide synthase expression in primary mouse macrophages. Moreover, CDDO-Im inhibits growth of B16 murine melanoma and L1210 murine leukemia cells in vivo. Injection of 10 nM (5.4 μg) of CDDO-Im almost completely blocks the ability of IFN-γ to induce iNOS, and treatment with as little as 1 nmol of CDDO-Im (0.54 μg) is partially effective.

相关产品：Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  Immunology/Inflammation Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Erastin  |  Ferrostatin-1  |  Cisplatin  |  Cycloheximide  |  RSL3  |  Acetylcysteine  |  Deferoxamine mesylate  |  SP600125  |  Necrostatin-1  |  Retinoic acid  |  Rosiglitazone  |  Resveratrol  |  SB 202190  |  GW9662  |  4-Octyl Itaconate  |  Curcumin  |  Hemin  |  (-)-Epigallocatechin Gallate  |  Sulforaphane  |  TBHQ  |  Simvastatin  |  Bardoxolone methyl  |  U-73122  |  Pifithrin-α hydrobromide  |  Luteolin  |  Lovastatin  |  Trolox  |  Eprenetapopt  |  L-Glutathione reduced  |  Dimethyl fumarate

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