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Pargyline hydrochloride

CAS No. : 306-07-0

MCE 站：Pargyline hydrochloride

产品活性：Pargyline hydrochloride 是一种不可逆的单胺氧化酶 (MAO) 抑制剂，对 MAO-A 和 MAO-B 的 K_i 分别为 13 μM 和 0.5 μM。Pargyline hydrochloride 具有降压和抗癌活性。

研究领域：Neuronal Signaling

作用靶点：Monoamine Oxidase

In Vitro: Pargyline (0.5-2 mM; 24-120 hours; LNCaP-LN3 cells) treatment inhibits the proliferation of prostate cancer cells in a time- and dose-dependent manner.
Pargyline (0.5-2 mM; 24-48 hours; LNCaP-LN3 cells) treatment decreases S phase and increases the G1 phase in the cells in a dose-dependent manner.
Pargyline (0.5 mM; 24 hours; LNCaP-LN3 cells) treatment increases the apoptotic cells.
Pargyline (2 mM; 48 hours; LNCaP-LN3 cells) treatment induces an increase of cytochrome c and a decrease of caspase-3 in the cells, but does not lead to a change of BCL-2 expression.

In Vivo: Pargyline (10 mg/kg; iv) treatment induces a moderate (about 20 mm Hg) but persistent (48 h) decrease of systolic blood pressure in unanesthetized adult spontaneously hypertensive rats (SHR) but not in normotensive rats.
A low dose of Pargyline (200 μg; icv) injected directly into the brain lowered arterial pressure. The hypotensive action of Pargylline in SHR appears to be the consequence of Norepinephrine accumulating at an inhibitory α-adrenoceptor in brain.

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