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Cinchophen

CAS No. : 132-60-5

MCE 站：Cinchophen

产品活性：Cinchophen 是一种具有口服活性的非甾体抗炎试剂 (anti-inflammatory agent)，具有镇痛和抗菌作用。Cinchophen 可用于关节炎和某些肝脏疾病的研究。

研究领域：Others

作用靶点：Others

In Vivo: Cinchophen (oral gavage; 25-44 mg/kg; twice daily) combines prednisolone ( 0.125-0.220 mg/kg; twice daily) for 14 days is effective in dogs with osteoarthritis and well tolerated. The combination exhibits significantly improved lameness, weight bearing, joint mobility and stiffness scores and is similar in clinical efficacy to phenylbutazone.
The kinetics and efficacy of a cinchophen prednisolone combination preparation (PLT) is tested. Cinchophen administation at a dose rate of 12.5 mg/kg intravenously exhibits a volume of distribution (V_d area) of 0.13 L/kg, shows a clearance rate (Cl) of 0.15 L/h and a half-life (t_1/2β) of 7.92 hours. The plasma concentration time curve (AUC0-∞) is 1187.0 μ/ml.h in dogs.
Cinchophen administation (oral gavage; 12.5 mg/kg; single dose) exhibits a mean maximum plasma concentration (C_max) of 77.75 μg/ml and the time of Cmax (t_max) is 2.76 hours. The plasma concentration time curve (AUC_0-∞) is almost as large following oral as intravenous administration indicating an oral bioavailability (F) of 87.21%.

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