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Quinacrine dihydrochloride
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Quinacrine dihydrochloride
CAS No. : 69-05-6
MCE 站:Quinacrine dihydrochloride
产品活性:Quinacrine (Mepacrine) dihydrochloride 是一种有效的,具有口服活性的抗疟剂 (antimalarial),在体内外均具有抗肿瘤作用。Quinacrine dihydrochloride 抑制 NF-κB 并激活 p53 信号转导,诱导肿瘤细胞发生凋亡 (apoptosis)。
研究领域:Anti-infection | Apoptosis | Autophagy
作用靶点:Parasite | Apoptosis | Autophagy | Mitophagy
In Vitro: Quinacrine (5-20 μM; 24 hours) inhibits the growth of SGC-7901 cells.
Quinacrine (7.5 and 15 μM; 24 hours) induces apoptosis in SGC-7901 cells, which is associated with mitochondria-dependent signal pathway and involves p53 upregulation and caspase-3 activation pathway.
Quinacrine (15 μM; 24 hours) treatment significantly increased the levels of proapoptotic proteins, including cytochrome c, Bax, and p53, and decreased the levels of antiapoptotic protein Bcl-2, thus shifting the ratio of Bax/Bcl-2 in favor of apoptosis .
In Vivo: Quinacrine (100 mg/kg three times per week for two consecutive weeks) significantly suppresses circulating blast cells at days 30/31 and increases the median survival time (MST). Quinacrine does not decrease the body weight of treated animals at the tested dose.
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