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Butylhydroxyanisole

CAS No. : 25013-16-5

MCE 站：Butylhydroxyanisole

产品活性：Butylhydroxyanisole (Butylated hydroxyanisole) 是一种抗氧化剂，用作食品防腐剂。Butylhydroxyanisole 能介导肝毒性、生殖器官发育和学习迟缓以及睡眠不足。Butylhydroxyanisole 具有神经毒性，能导致大脑和神经发育中断。Butylhydroxyanisole 也是一个铁死亡 (ferroptosis) 诱导剂。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Reactive Oxygen Species  |  Ferroptosis

In Vitro: Butylhydroxyanisole exerts neurotoxic effects by promoting cytosolic calcium accumulation and endoplasmic reticulum stress in astrocytes.
Butylhydroxyanisole (25-100 μM; 48 hours) inhibits growth and induces death in human astrocytes.
Butylhydroxyanisole (100 μM; 48 hours) decreases the expression of cell-cycle-related proteins and increased the expression of the cell cycle inhibitory protein.
Butylhydroxyanisole (100 μM; 48 hours) mediates apoptotic signals in NHA-SV40LT Cells.
Butylhydroxyanisole also increases the cytosolic calcium level and the expression of endoplasmic reticulum stress proteins.
Butylhydroxyanisole induces testicular dysfunction in mouse testis cells by dysregulating calcium homeostasis and stimulating endoplasmic reticulum stress.

In Vivo: Butylhydroxyanisole (200 mg/kg; i.g.; daily; for three days) induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice.

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