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Alda-1

CAS No. : 349438-38-6

MCE 站：Alda-1

产品活性：Alda-1是有效的 ALDH2 激动剂，其激活野生型ALDH2并恢复近似野生型活性至ALDH2*2。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Aldehyde Dehydrogenase (ALDH)  |  Apoptosis

In Vivo: Alda-1 treatment results in a significant decrease of 4-HNE-protein content in the plasma of apoE^?/? mice. Alda-1 administration leads to a slight increase in gene expression related to neurogenesis (Nog), mitochondrial biogenesis (CYTB, ND1), and apoptosis (Bax, Gsk3b) in the Hp of apoE^?/? mice. Alda-1 administration leads to 2 and 10 differentially expressed proteins in the FCx and Hp of apoE^?/? mice, respectively. Alda-1 (1.5 mg/kg, b.w., i.p.) administration significantly increases the climbing time, tends to reduce the immobility time and increases the swimming time of the prenatally stressed rats in the forced swim test. Moreover, treatment of prenatally stressed rats with Alda-1 significantly increases number of entries into the open arms of the maze and the time spent therein, as assessed by elevated plus-maze test. Alda-1 (8.5 mg/kg, i.p.) with glucose significantly lowers 4-HNE and FJB-positive cells in the cerebral cortex of Alda-1-treated rats than in DMSO-treated rats 24 h after glucose administration. Alda-1 (10 mg/kg per day) treatment prevents aldehydic overload, mitochondrial dysfunction and improves ventricular function in post-MI cardiomyopathy rats.

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