MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Tolmetin sodium dihydrate

CAS No. : 64490-92-2

MCE 站：Tolmetin sodium dihydrate

产品活性：Tolmetin sodium dehydrate 是一种具有口服活性的，有效的 COX 抑制剂，对人 COX-1 和 COX-2 的 IC₅₀ 值分别为 0.35 ?M 和 0.82 ?M。Tolmetin sodium dehydrate 属于非甾体类物质，具有强效的抗炎活性。

研究领域：Immunology/Inflammation

作用靶点：COX

In Vitro: Tolmetin sodium dihydrate (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat.
Tolmetin sodium dihydrate (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner.
Tolmetin sodium dihydrate (0-100 μM) shows no effect on osteoblast growth.

In Vivo: Tolmetin sodium dihydrate (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg.
Tolmetin sodium dihydrate (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Ferroptosis Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  Pyroptosis Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Acetaminophen  |  Indomethacin  |  Celecoxib  |  Aspirin  |  Ibuprofen  |  Catechin  |  NS-398  |  Diclofenac  |  20(S)-Ginsenoside Rg3  |  Naproxen  |  (-)-Epicatechin  |  Gallic acid  |  Xanthohumol  |  Sulindac  |  SC-560  |  Carprofen  |  Salicylic acid  |  Meloxicam  |  Rutaecarpine  |  Rebamipide  |  Iguratimod  |  Flufenamic acid  |  Fenofibric acid  |  Isoorientin  |  Nabumetone  |  Neochlorogenic acid  |  Piroxicam  |  Rofecoxib

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。