您好,欢迎来到易推广 请登录 免费注册

MedChemExpress 主营产品:Medchemexpress,抑制剂专家,生物试剂公司

易推广认证请放心拨打

021-58955995

当前位置: 易推广 > 生物试剂/抗体/细胞 > 生化试剂 > 其他 > MedChemExpress > 产品展示 > MCE信号通路 > PI3K/Akt/mTOR 信号通路 > A-674563 hydrochloride

提示:信息由商家自行发布,信息的真伪性请消费者自己判断,信息内容的准确性由相关商家负责,易推广对此不承担任何责任。

A-674563 hydrochloride

价格:¥电议

品牌名称:$brandModel.Title(进口品牌)型号: 原产地:美洲 发布时间:2021/7/30更新时间:2024/1/2

产品摘要:A-674563 hydrochloride 是具有选择性的高效 Akt1 抑制剂,其 Ki 值为 11 nM。

产品完善度: 访问次数:1600

企业档案

会员类型:会员

已获得易推广信誉   等级评定
171成长值

(0 -40)基础信誉积累,可浏览访问

(41-90)良好信誉积累,可接洽商谈

(91+  )优质信誉积累,可持续信赖

易推广会员:8

工商认证 【已认证】

最后认证时间:

注册号: 【已认证】

法人代表: 【已认证】

企业类型:生产商 【已认证】

注册资金:人民币万 【已认证】

产品数:91228

参观次数:11301145

手机网站:http://m.yituig.com/c131527/

旗舰版地址:http://medchemexpress.app17.com

联系我们

MedChemExpress

电话:021-58955995

联系人:客服部 (请说明是在易推广看到的!谢谢)

手机:13611715263

邮编:201203

邮箱:sales@medchemexpress.cn

地址:上海上海

详细内容

联系方式:
电话:021-58955995 手机:13611715263 联系人:客服部   Q Q:4008203792

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。

A-674563 hydrochloride

CAS No. :

MCE 站:A-674563 hydrochloride

产品活性:A-674563 hydrochloride 是具有选择性的高效 Akt1 抑制剂,其 Ki 值为 11 nM。

研究领域:PI3K/Akt/mTOR

作用靶点:Akt

In Vitro: A-674563 slows proliferation of tumor cells with an EC50 of 0.4 μM. A563 (0-10 ?M) significantly decreases GSK3 and MDM2 phosphorylation in STS cells. A563 shows inhibitory effect on all STS cell lines, with IC50 values at 48 hours ranging from 0.22±0.034 ?M (SW684) to 0.35 ±0.06 ?M (SKLMS1). A563 induces G2 cell cycle arrest and apoptosis in STS cells. A563 (1 ?M/12 hr) upregulates the expression of GADD45A independent of p53. A-674563 (10-1000 nM) is anti-proliferative and cytotoxic in cultured human melanoma cells, induces melanoma cell apoptotic death, inhibited by caspase inhibitors, and inhibits melanoma cells via Akt-dependent and -independent mechanisms. A-674563 is cytotoxic and anti-proliferative when added to U937 and AmL progenitor cells, activates caspase-3/9 and apoptosis in U937 and AmL progenitor cells, and manipulates other signalings in AmL cells whiling blocking Akt.

In Vivo: A-674563 (40 mg/kg/d, p.o.) shows no significant monotherapy activity, but the efficacy of the combination therapy (A-674563+paclitaxel) is significantly improved in the PC-3 prostate cancer xenograft model. A-674563 (20, 100 mg/kg) increases plasma insulin in an oral glucose tolerance test. A563 (20 mg/kg/bid; p.o.) exhibits slow tumor growth and a significant difference in tumor volume without significant weight loss of mice. A563-treated tumors express increased levels of GADD45α and decreased levels of PCNA (a nuclear marker for proliferation). Additionally, TUNEL assay staining levels (marker for apoptosis) increase in the A563-treated specimens. A-674563 (25, 100 mg/kg, lavage daily) potently inhibits A375 xenograft growth in mice. A-674563 (15, 40 mg/kg) injection inhibits U937 xenograft in vivo growth, and improves mice survival.

相关产品:Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Differentiation Inducing Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Honokiol  |  GSK-690693  |  Artemisinin  |  Oridonin  |  Perifosine  |  Guggulsterone  |  Miransertib  |  Triciribine  |  Recilisib  |  SU6656  |  Isobavachalcone  |  Scutellarin  |  Deguelin  |  Miltefosine  |  α-Linolenic acid  |  YS-49  |  Urolithin B  |  Polyphyllin I  |  Pachymic acid  |  3CAI  |  1,3-Dicaffeoylquinic acid  |  Esculetin  |  Cyclovirobuxine D  |  Licochalcone E  |  SC66  |  Akt1 and Akt2-IN-1  |  Arnicolide D  |  Loureirin A  |  N-Oleoyl glycine

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物;
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
•   设有专业的实验中心和严格的质控、验证体系;
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
•   产品的生物活性多经各国客户实验验证;
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
•   专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
•   与世界各大制药公司及知名科研机构建立了长期的合作。

1000+ Inhibitors&Agonists 作用于20多条经典信号通路
30+ Screening Libraries 疾病机制研究的高效工具
CCK8 Kit | Cell Counting Kit-8
FDA-Approved 药物筛选库
Inhibitor Cocktails 蛋白酶, 磷酸酶 & 去乙酰化酶
Top Publications Citing Use of MCE
MCE Hotline: 4008203792 | 中国现货 - 全球文献引用 - 高纯度高品质 - 全方位技术支持
联系方式:
电话:021-58955995 手机:13611715263 联系人:客服部   Q Q:4008203792

热门标签:a 674563 

快速导航

在线咨询

提交