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TBHQ

CAS No. : 1948-33-0

MCE 站：TBHQ

产品活性：TBHQ (tert-Butylhydroqui) 是一种广泛使用的 Nrf2 激活剂，通过激活 Nrf2 来免受 Doxorubicin (DOX)-诱导的心脏毒性。TBHQ (tert-Butylhydroqui) 也是一种 ERK 激活剂，逆转 Dehydrocorydaline (DHC) 对黑素瘤细胞增殖的抑制作用。

研究领域：NF-κB  |  Stem Cell/Wnt  |  MAPK/ERK Pathway  |  Autophagy  |  Apoptosis

作用靶点：Keap1-Nrf2  |  ERK  |  Autophagy  |  Apoptosis  |  Ferroptosis

In Vitro: TBHQ (t-butylhydroqui; tBHQ; 0-100 μM; 48 hours; H9c2 cells) alone does not affect H9c2 cells viability. Pre-incubation of the H9c2 cells with various concentrations of tBHQ for 24 hours enhances cell viability which is decreased due to exposure to ethanol in a dose-dependent manner. Treatment with tBHQ markedly enhances the viability of H9c2 cardiomyocytes exposed to ethanol.
TBHQ (5 μM; 15 min; H9c2 cells) treatment significantly reduces the amount of apoptotic cells exposed to ethanol.
TBHQ (5 μM; H9c2 cells) pre-treatment markedly inhibites the ethanol-induced increase in caspase-3 and Bax expression, and enhances Bcl-2 expression.

In Vivo: TBHQ treatment (50 mg/kg; Intraperitoneal injection; three injections at intervals of 8 h that began 1-h post ICH; CD-1 mice) augments the DNA-Binding activity of Nrf2, attenuates oxidative brain damage and acute neurological deficits afterintracerebral hemorrhage (ICH), attenuates microglial activation with concomitant reduction in the release of proinflammatory cytokine interleukin-1β (IL-1β). TBHQ has the efficacy of post-injury administration in attenuating acute neurological injury after ICH.

相关产品：Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  MAPK Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Fragment Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Pyroptosis Compound Library  |  Glutamine Metabolism Compound Library  |  Neuroprotective Compound Library  |  MG-132  |  Erastin  |  Ferrostatin-1  |  Cisplatin  |  LY294002  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Paclitaxel  |  Cycloheximide  |  Y-27632 dihydrochloride  |  RSL3  |  Acetylcysteine  |  Angiotensin II human  |  Deferoxamine mesylate  |  SP600125  |  5-Fluorouracil  |  Staurosporine  |  Bortezomib  |  Tamoxifen  |  2-Deoxy-D-glucose  |  Gemcitabine  |  Necrostatin-1  |  PD98059  |  Verteporfin  |  Decitabine  |  Actinomycin D  |  Temozolomide  |  BAY 11-7082  |  Etoposide

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