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SRI-011381 hydrochloride
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SRI-011381 hydrochloride
CAS No. : 2070014-88-7
MCE 站:SRI-011381 hydrochloride
产品活性:SRI-011381 hydrochloride 是有口服生物活性的 TGF-beta 信号通路的激活剂,具有神经保护作用。
研究领域:Stem Cell/Wnt | TGF-beta/Smad
作用靶点:TGF-beta/Smad
In Vitro: SRI-011381 hydrochloride promotes fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages.
SRI-011381 hydrochloride (10 μM) eliminates Saikosaponin A (SSA, 30 μM)-induced protective effects on fibroblasts.
In Vivo: SRI-011381 hydrochloride protects mice against kainic acid-induced excitotoxicity and neurodegeneration.
SRI-011381 hydrochloride (10-75 mg/kg; p.o.; 14 days) results in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin.
SRI-011381 hydrochloride (30 mg/kg; i.p.) activates TGF-β signaling in SBE-luciferase bioluminescent reporter mice.
SRI-011381 hydrochloride is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%.
SRI-011381 hydrochloride reduces neurodegeneratio in APP751Lon, Swetransgenic mice.
相关产品:Bioactive Compound Library Plus | Stem Cell Signaling Compound Library | TGF-beta/Smad Compound Library | Wnt/Hedgehog/Notch Compound Library | CNS-Penetrant Compound Library | Anti-Aging Compound Library | Differentiation Inducing Compound Library | Neuroprotective Compound Library | Pirfenidone | (E)-SIS3 | Kartogenin | Asiaticoside | Halofugi | Oxymatrine | Hydrochlorothiazide | Disitertide | Alantolactone | Trimethylamine N-oxide | Chebulinic acid | Butaprost | 10,11-Dehydrocurvularin
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