MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

KN-93 phosphate

CAS No. : 1913269-12-1

MCE 站：KN-93 phosphate

产品活性：KN-93是钙离子/钙调蛋白依赖激酶II（CaMKII）抑制剂，能竞争性阻断钙调蛋白与对应激酶的结合，Ki为370 nM。

研究领域：Neuronal Signaling  |  Autophagy

作用靶点：CaMK  |  Autophagy

In Vitro: After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H⁺, K⁺-ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca²⁺-independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Neuronal Signaling Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  KN-93  |  STO-609  |  K-252a  |  KN-62  |  A-484954  |  NH125  |  Calmidazolium chloride  |  W-7 hydrochloride  |  MLCK inhibitor peptide 18  |  CaMKII-IN-1  |  Autocamtide-2-related inhibitory peptide TFA  |  Syntide 2 TFA  |  Rimacalib  |  A-3 hydrochloride  |  Autocamtide 2  |  Calmodulin-Dependent Protein Kinase II(290-309) acetate  |  Autocamtide-2-related inhibitory peptide, myristoylated  |  Lavendustin C  |  Psoralenoside  |  Autocamtide 2, amide  |  Metofenazate

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。