当前位置: 易推广 > 生物试剂/抗体/细胞 > 生化试剂 > 其他 > MedChemExpress > 产品展示 > MCE信号通路 > 跨膜转运 > ZSET1446
ZSET1446
企业档案
会员类型:会员
已获得易推广信誉 等级评定
(0 -40)基础信誉积累,可浏览访问
(41-90)良好信誉积累,可接洽商谈
(91+ )优质信誉积累,可持续信赖
易推广会员:8年
最后认证时间:
注册号: 【已认证】
法人代表: 【已认证】
企业类型:生产商 【已认证】
注册资金:人民币万 【已认证】
产品数:91196
参观次数:10678595
联系我们
MedChemExpress
电话:021-58955995
联系人:客服部 (请说明是在易推广看到的!谢谢)
手机:13611715263
邮编:201203
邮箱:sales@medchemexpress.cn
地址:上海上海
详细内容
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
ZSET1446
CAS No. : 887603-94-3
MCE 站:ZSET1446
产品活性:ZSET1446 是一种新颖的促进认知药,在不同的阿尔茨海默病模型中,能够改善学习功能障碍。
研究领域:Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点:Calcium Channel | nAChR
In Vitro: ZSET1446 (100 pM-10 nM) exerts limited effects on the basal neuronal excitability and synaptic transmission. ZSET1446 potentiates the facilitatory effect of nAChR stimulation on sPSC frequency. ZSET1446 potentiates the increase in sIPSC frequency by local application of nicotine (5 ?M; 2 minutes) without affecting the basal sIPSC frequency at the range of 10 pM to 1 nM.
In Vivo: ZSET1446 enhances object recognition memory in mice and ameliorates cognitive impairment caused by scopolamine in rats. Concomitant administration of subeffective doses of ZSET1446 and memantine significantly ameliorates the cognitive performance in the novel object recognition task in both mice and rats. Moreover, oral administration of ZSET1446 or memantine increases the extracellular level of ACh in the hippocampus as compared with the control. Further, concomitant administration of subeffective doses of ZSET1446 and memantine significantly increases the extracellular level of ACh as compared with the group of ZSET1446 or memantine alone. ZSET1446 (0.002, 0.01, and 0.1 mg/kg, p.o.) ameliorates cognitive deficits of SAMP8 after 4, 8, 12, and 16 weeks of treatment in a novel object recognition test. ZSET1446 also reduces grading scores of SAMP8 after 16 weeks of treatment. Further, 8-week treatment of ZSET1446 significantly reduces the total number of Aβ-positive granules in the hippocampus.
相关产品:Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | Reprogramming Compound Library | Anti-COVID-19 Compound Library | Neurotransmitter Receptor Compound Library | Anti-Alzheimer’s Disease Compound Library | Ionomycin | L-Ascorbic acid | Thapsigargin | Verapamil hydrochloride | Ebselen | Methyllycaconitine citrate | Nifedipine | Fasudil Hydrochloride | 2-Aminoethyl diphenylborinate | Acetylcholine chloride | GSK1016790A | Tetrandrine | PNU-282987 | Mibefradil dihydrochloride | CDN1163 | GTS-21 dihydrochloride | Nimodipine | Gabapentin | L-Phenylalanine | Penfluridol | Diltiazem hydrochloride | Istaroxime hydrochloride | Cromolyn sodium | GSK-7975A | (S)-(-)-Bay-K-8644 | Ethacrynic acid | Felodipine | Cilnidipine
品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物;
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
• 专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。
热门标签:ST-101