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NSC23005 sodium

CAS No. : 1796596-46-7

MCE 站：NSC23005 sodium

产品活性：NSC23005 sodium 是一种新型有效的 p18 抑制剂 (ED₅₀=5.21 nM)，在小鼠和人类模型中促进造血干细胞 (HSCs) 扩增。

研究领域：Others

作用靶点：Others

In Vitro: NSC23005 sodium (Compound 40) is a novel class of INK4C (p18^INK4C or p18) small molecule inhibitor (p18SMIs), which is initially found by in silico 3D screening. NSC23005 sodium shows the most potent bioactivity in hematopoietic stem cells (HSCs) expansion (ED₅₀=5.21 nM). Notably, NSC23005 sodium does not show significant cytotoxicity toward 32D cells or HSCs, nor does it augment leukemia cell proliferation. NSC23005 sodium (ED₅₀=5.21 nM), shows no activity in promoting the proliferation of leukemia cells.

In Vivo: NSC23005 sodium selectively promote HSCs division by inhibiting p18, thereby activating CDK4/6. NSC23005 sodium is a novel and effective p18 inhibitor in promoting HSCs expansion in both murine and human models.

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