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Tenofovir alafenamide hemifumarate

CAS No. : 1392275-56-7

MCE 站：Tenofovir alafenamide hemifumarate

产品活性：Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) 是 Tenofovir 的前体，Tenofovir 是一种 HIV-1 核苷酸逆转录酶抑制剂。

研究领域：Anti-infection

作用靶点：HIV  |  Reverse Transcriptase

In Vitro: Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC₅₀ varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC₅₀s range from 0.1 to 12 nM, with a mean EC₅₀ of 3.5 nM compared to a mean EC₅₀ of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC₅₀s are 1.8 nM for TAF and 6.4 nM for AZT.

In Vivo: Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF) .

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