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SF1670

CAS No. : 345630-40-2

MCE 站：SF1670

产品活性：SF1670 是一种有效的特异性的人第10号染色体缺失的磷酸酶及张力蛋白同源蛋白 (PTEN) 抑制剂。

研究领域：PI3K/Akt/mTOR  |  Metabolic Enzyme/Protease  |  Autophagy

作用靶点：PTEN  |  Phosphatase  |  Autophagy

In Vitro: SF1670 is a specific PTEN inhibitor with prolonged intracellular retention in neutrophils. SF1670 enhances PtdIns(3,4,5)P3 signaling in transplanted neutrophils. SF1670 also elevates Akt phosphorylation in murine cells. Consistent with the enhanced Akt phosphorylation, pretreatment with SF1670 also significantly augments PtdIns(3,4,5)P3 level in mouse neutrophils. SF1670-induced Akt hyperactivation is abolished in PTEN-null neutrophils, further demonstrating that this effect is mediated by specific inhibition of PTEN activity. At 500 nM fMLP stimulation, SF1670 (500 nM)–pretreated neutrophils show nearly 70% higher (maximal) superoxide production than untreated neutrophils. HCT116 cells are pre-treated with the PTEN inhibitor SF1670 (2 μM) for 24 h (untreated HCT116 cells served as control); treated cells are subsequently plated under non-adherent conditions with added MET (60 μM), Lun (2 μM), or Gen (2 μM). SF1670 binds to the PTEN active site, resulting in elevated phosphatidylinositol (3,4,5) triphosphate signaling.

In Vivo: SF1670 (3 mg/kg; i.p.) triggers postconditioning after inducing cerebral global ischaemia (17 min) and reperfusion (24 h)‐induced injury via occlusion of both carotid arteries in mice.

相关产品：Natural Product Like Compound Library  |  Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  PI3K/Akt/mTOR Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Phosphatase Inhibitor Library  |  Cyclosporin A  |  Tacrolimus  |  Ebselen  |  Salubrinal  |  Suramin sodium salt  |  Calyculin A  |  β-Glycerophosphate disodium salt pentahydrate  |  Sodium orthovanadate  |  TPI-1  |  VO-Ohpic trihydrate  |  MSI-1436 lactate  |  GSK 2830371  |  NSC 663284  |  Okadaic acid  |  D-erythro-Sphingosine  |  Sodium metatungstate  |  BCI  |  Sodium stibogluconate  |  Voclosporin  |  MB05032  |  Pentamidine isethionate  |  3α-Aminocholestane  |  ARL67156 trisodium salt  |  BVT948  |  PTP1B-IN-2  |  KY-226  |  GNF362  |  L-690330

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