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Phenylephrine

CAS No. : 59-42-7

MCE 站：Phenylephrine

产品活性：(R)-(-)-Phenylephrine是选择性的α₁-肾上腺素受体激动剂，主要用作减充血剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Adrenergic Receptor

In Vitro: (R)-(-)-Phenylephrine is a selective α₁-adrenoceptor agonist with pK_i values of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively. Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(²⁺)/CaN/NFAT pathway mediates phenylephrine -induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis.

In Vivo: Perfusion of hearts with 100 μM phenylephrine causes a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α₁-adrenoceptor agonists such as phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes. Phenylephrine could increase the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Endocrinology Compound Library  |  Orally Active Compound Library  |  Neurotransmitter Receptor Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Isoprenaline hydrochloride  |  ICI 118,551 hydrochloride  |  Propranolol hydrochloride  |  Norepinephrine  |  Phenylephrine hydrochloride  |  Pimozide  |  Yohimbine Hydrochloride  |  Olanzapine  |  Prazosin hydrochloride  |  Atenolol  |  Carvedilol  |  CL 316243  |  Amitriptyline hydrochloride  |  Dexmedetomidine hydrochloride  |  L-Epinephrine  |  Metoprolol Succinate  |  YS-49  |  Pindolol  |  Dobutamine hydrochloride  |  Nebivolol hydrochloride  |  Salmeterol  |  Labetalol hydrochloride  |  Perphenazine  |  (S)-Timolol Maleate  |  (±)-Bisoprolol hemifumarate  |  Phentolamine mesylate  |  Terazosin hydrochloride dihydrate  |  Ivabradine hydrochloride  |  Paliperidone

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