MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Bay 41-4109 racemate

CAS No. : 298708-79-9

MCE 站：Bay 41-4109 racemate

产品活性：BAY 41-4109 racemate是BAY 41-4109的消旋体。BAY 41-4109是人乙型肝炎病毒HBV的有效抑制剂，IC₅₀值为53 nM。

研究领域：Anti-infection

作用靶点：HBV

In Vitro: BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro. Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC₅₀s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition.

In Vivo: BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs.BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid.

相关产品：Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Antiviral Compound Library  |  Doxorubicin hydrochloride  |  OSS_128167  |  Entecavir monohydrate  |  Tenofovir  |  Merimepodib  |  Osthole  |  4,5-Dicaffeoylquinic acid  |  Punicalagin  |  Adefovir dipivoxil  |  Osalmid  |  Telbivudine  |  Isochlorogenic acid A  |  Oxethazaine  |  Adefovir  |  Bicyclol  |  Catalpol  |  Bay 41-4109  |  Clevudine  |  Squalamine  |  Tenofovir Disoproxil  |  Pseudolaric Acid B  |  Thiamine hydrochloride  |  Cetylpyridinium chloride  |  Bifendate  |  Punicalin  |  RO8191  |  Taribavirin hydrochloride  |  Alisol F  |  4-Hydroxyacetophe

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。