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RIPA-56

CAS No. : 1956370-21-0

MCE 站：RIPA-56

产品活性：RIPA-56 是一种高效选择和代谢稳定的受体相互作用蛋白 1 (RIP1) 抑制剂，IC₅₀ 为 13 nM。RIPA-56 可用于研究全身炎症反应综合征。

研究领域：Apoptosis

作用靶点：RIP kinase

In Vitro: RIPA-56 shows efficient inhibition of RIP1 kinase activity, with an IC₅₀ of 13 nM and no inhibition of RIP3 kinase activity at a 10 μM concentration. RIPA-56 also demonstrates potency in protection of murine L929 cells from TNFα/z-VAD-FMK (TZ)-induced necrosis (EC₅₀=27 nM).

In Vivo: In the SIRS mice disease model, RIPA-56 efficiently reduces tumor necrosis factor alpha (TNFα)-induced mortality and multi-organ damage. Compared to known RIP1 inhibitors, RIPA-56 is potent in both human and murine cells, is much more stable in vivo, and is efficacious in animal model studies. RIPA-56 has an impressive PK profile in mice with a 3.1 h half-life, 22% oral bioavailability (P.O.), and 100% bioavailability from intraperitoneal injection (I.P.).

相关产品：Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  NF-κB Signaling Compound Library  |  Necrostatin-1  |  GSK-872  |  GSK583  |  GSK840  |  GSK-843  |  HS-1371  |  RIP2 kinase inhibitor 2  |  PROTAC RIPK degrader-2  |  RIPK-IN-4  |  RIPK1-IN-4  |  RIPK1-IN-7  |  PROTAC RIPK degrader-6  |  Kongensin A  |  GNE684  |  cRIPGBM

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