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Brivudine

CAS No. : 69304-47-8

MCE 站：Brivudine

产品活性：Brivudine是具有抗病毒活性的胸苷类似物,用于早期急性带状疱疹的研究。

研究领域：Anti-infection

作用靶点：CMV

In Vitro: Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage.

In Vivo: At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia.

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