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Diquafosol tetrasodium

CAS No. : 211427-08-6

MCE 站：Diquafosol tetrasodium

产品活性：Diquafosol tetrasodium 是一种P2Y2受体激动剂，可刺激眼睛表面的液体和粘蛋白分泌，用于干眼病的研究。

研究领域：GPCR/G Protein

作用靶点：P2Y Receptor

In Vitro: Cell viability significantly decreased after treatment with 30% diluted diquafosol for 1 hour and 6 hours after treatment with 10% and 20% diluted diquafosol. Twenty-four hours after wounding monolayers, 3% diquafosol, and 0.3% HCECs exhibits significantly more wound healing than the control.

In Vivo: In a rat dry eye model, the P2Y2 agonist diquafosol tetrasodium is found to improve surface health, based on increases in tear fluid secretion, corneal epithelial resistance, and release of glycoprotein-containing moieties from goblet cells. Beginning at 2 weeks and continuing for an additional 2 weeks, maximal declines in dye penetrance of approximately 50% occurred with doses of diquafosol tetrasodium as low as 1%. INS365 significantly suppresses corneal damage at concentrations of more than 0.1% w/v.

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