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Clinofibrate

CAS No. : 30299-08-2

MCE 站：Clinofibrate

产品活性：Clinofibrate (S-8527)是一种降血脂药和一种HMG-CoA还原酶抑制剂。

研究领域：Metabolic Enzyme/Protease  |  Autophagy

作用靶点：HMG-CoA Reductase (HMGCR)  |  Autophagy

In Vivo: Clinofibrate administration (50 and 100 mg/kg/day, p.o.) significantly inhibits the increase in plasma fibrinogen level as well as serum- and VLDL-LDL-lipids. Clinofibrate significantly decreases the high plasma cholesterol level of atherosclerotic rats, which is 823±256 mg/dl, or about ten times that of control rats (85±11 mg/dl). On treatment with clinofibrate, the cholesterol level is reduced most in the very low density lipoprotein (VLDL) fraction. In rats which are refed either a fat-free diet or a 5% fat diet after a 2-day fast. clinofibrate at 30 mg/kg results in reductions of serum and liver triglyceride levels. Oral ingestion of S-8527 to normal rats for 7 days lowers serum triglycerides and cholesterol by about 27% at 1 mg/kg and 20% at 3 mg/kg, respectively. S-8527 at 3 mg/kg decreases liver triglyceride concentration by about 20%.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  FDA-Approved Drug Library  |  Autophagy Compound Library  |  Drug Repurposing Compound Library  |  Ferroptosis Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Simvastatin  |  Lovastatin  |  Atorvastatin hemicalcium salt  |  Rosuvastatin Calcium  |  Mevastatin  |  Fluvastatin sodium  |  Pitavastatin Calcium  |  Pravastatin sodium  |  Meglutol  |  SR12813  |  Cerivastatin sodium  |  Hesperetin 7-O-glucoside  |  (3R,5R)-Rosuvastatin  |  (3R,5S)-Fluvastatin  |  (3S,5R)-Rosuvastatin  |  (Rac)-5-Keto Fluvastatin  |  (rel)-Atorvastatin  |  2'-Ethyl Simvastatin  |  3α-Hydroxy pravastatin sodium  |  Atorvastatin lactone

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