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Ilaprazole
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Ilaprazole
CAS No. : 172152-36-2
MCE 站:Ilaprazole
产品活性:Ilaprazole (IY-81149),一种具有口服活性质子泵抑制剂,以剂量依赖性方式不可逆地抑制 H+/K+-ATPase,在兔壁细胞制剂中的 IC50 为 6 μM。Ilaprazole 用于胃溃疡的研究。Ilaprazole 也是一种有效的T细胞起源蛋白激酶 (TOPK) 抑制剂。
研究领域:Membrane Transporter/Ion Channel | Cell Cycle/DNA Damage
作用靶点:Proton Pump | TOPK
In Vitro: On cumulation of 14C-aminopyrine in histamine stimulated parietal cells, the IC50 of Ilaprazole (IY-81149) sodium is 9 nM.
In Vivo: Ilaprazole (3-30 mg/kg; i.d.) dose-dependently inhibits gastric acid secretion.
In anesthetized rats, Ilaprazole dose-dependently increased gastric pH which was lowered by histamine infusion. In the case of i.v. injection, the ED50 of Ilaprazole and omeprazole is 1.2 and 1.4 mg/kg and in the case of i.d. administration, the ED50 of Ilaprazole and omeprazole is 3.9 and 4.1 mg/kg, respectively. Ilaprazole also significantly inhibits pentagastrin-stimulated gastric secretion. Its ED50 is 2.1 mg/kg and that of Omeprazole is 3.5 mg/kg with i.d. administration. In the case of i.v. injection, Ilaprazole is equipotent to Omeprazole. Ilaprazole also inhibits gastric acid secretion strongly in fistular rats. The ED50 of Ilaprazole administered intraduodenally is 0.43 mg/kg and that of Omeprazole is 0.68 mg/kg.
相关产品:Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | Membrane Transporter/Ion Channel Compound Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | NMPA-Approved Drug Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Bafilomycin A1 | Omeprazole | Rabeprazole sodium | Concanamycin A | Lansoprazole | Zinc Pyrithione | HI-TOPK-032 | Thonzonium bromide | Pantoprazole sodium | Esomeprazole sodium | Abscisic acid | Soraprazan | Linaprazan | Cephradine | SCH28080 | Tiludronate disodium | Chebulinic acid | Verucopeptin | Diphyllin | Ilaprazole sodium | Manzamine A hydrochloride | (±)?-?Vasicine | 5-Hydroxylansoprazole
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热门标签:IY-81149