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Lodoxamide tromethamine

CAS No. : 63610-09-3

MCE 站：Lodoxamide tromethamine

产品活性：Lodoxamide tromethamine (U-42585E) 是作为肥大细胞稳定剂的抗过敏化合物, 用于研究哮喘和过敏性结膜炎。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor

In Vitro: lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced ⁴⁵Ca influx with associated histamine release in purified rat peritoneal mast cells.

In Vivo: Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model3 and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anesthetized rhesus monkeys. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation, decreased microvascular permeability, and increased compliance. Patients treated with lodoxamide tromethamine demonstrate an improvement in daytime breathing difficulty, cough, sputum production, and sleep.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Immunology/Inflammation Compound Library  |  Neuronal Signaling Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Endocrinology Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  Orally Active Compound Library  |  Neurotransmitter Receptor Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Histamine  |  Clemastine fumarate  |  Amitriptyline hydrochloride  |  Astemizole  |  Fexofenadine hydrochloride  |  Osthole  |  Terfenadine  |  Famotidine  |  Diphenhydramine hydrochloride  |  Levocetirizine dihydrochloride  |  Perphenazine  |  Loratadine  |  Cimetidine  |  Chlorprothixene  |  Lodoxamide  |  Pitolisant hydrochloride  |  Rupatadine Fumarate  |  Desloratadine  |  Latrepirdine dihydrochloride  |  Mianserin hydrochloride  |  Mirtazapine  |  Ebastine  |  Azelastine hydrochloride  |  Ritanserin  |  Chlorpheniramine maleate  |  Mepyramine maleate  |  Cinnarizine  |  Ranitidine hydrochloride  |  Clemizole hydrochloride

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