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MBP146-78

CAS No. : 188343-77-3

MCE 站：MBP146-78

产品活性：MBP146-78是有效的选择性的cGMP依赖的蛋白激酶抑制剂。

研究领域：Anti-infection

作用靶点：Parasite

In Vitro: MBP146-78 displays a dose-dependent inhibition of T. gondii tachyzoites replicating inside HFFs, with an IC₅₀ of 210 nM. The suppression of lytic parasite growth by MBP146-78 is reversible. Replacement of the medium with medium lacking MBP146-78, after treatment for up to 7 days at 2 μM, results in complete lysis of HFF cell monolayers. MBP146-78 is neither toxic nor inhibitory to proliferating or confluent monolayers of HFFs at concentrations of up to 10 μM.

In Vivo: In infected mice that are treated with MBP146-78 at 50 mg/kg twice daily, parasites are undetectable throughout the 10-day treatment period in each of the tissues examined. However, samples from brain, spleen, and lung taken from infected treated mice reveal the presence of parasites after cessation of administration of MBP146-78, indicating that a transient asymptomatic parasite recrudescence occurs in all survivors. The ability of mice to control Toxoplasma infection after MBP146-78 treatment has been terminated suggests that the mouse immune system plays a synergistic role with chemotherapy in controlling the infection.

相关产品：Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Kinase Inhibitor Library  |  Chloroquine  |  Hydroxychloroquine sulfate  |  Ivermectin  |  Kaempferol  |  Metronidazole  |  Dihydroartemisinin  |  Niclosamide  |  Suramin sodium salt  |  Artesunate  |  Artemisinin  |  Quinidine  |  Halofugi  |  Miransertib  |  Mefloquine hydrochloride  |  Quinacrine dihydrochloride  |  Sanguinarine chloride  |  Amodiaquine dihydrochloride dihydrate  |  Ascomycin  |  Mebendazole  |  Atovaquone  |  Methylene Blue  |  Bithionol  |  Diminazene aceturate  |  Okadaic acid  |  Quinine  |  Urethane  |  Levamisole hydrochloride  |  Osthole  |  Fenbendazole

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