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SU1498
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SU1498
CAS No. : 168835-82-3
MCE 站:SU1498
产品活性:SU1498 (AG 1498) 是选择性的 VEGFR2 抑制剂;抑制 Flk-1 的 IC50 值为 700 nM。
研究领域:Protein Tyrosine Kinase/RTK
作用靶点:VEGFR
In Vitro: SU1498 stimulates accumulation of phosphorylated ERKs in human umbilical vein endothelial cells and in human aortic endothelial cells in a manner that is dependent on the functioning of the upstream components of the MAPK pathway, B-Raf, and MEK kinases. The enhanced accumulation of phospho-ERKs is observed only in cells that have been stimulated with sphingosine 1-phosphate or protein growth factors; SU1498 by itself is ineffective. SU1498 blocks signal transduction from VEGFR2 in MS1 VEGF cells.In the presence of SU1498, levels of Ets-1 are decreased, suggesting that VEGF-VEGFR-2 interactions contributed to baseline levels of Ets-1 expression, and interruption of this autocrine interaction with SU1498 led to decreased expression of Ets-1. SU1498 treatment significantly impacts U87 cell proliferation and apoptosis. SU1498 induces a marked increase in lipids and a decrease in glycerophosphocholine. Accordingly, accumulation of lipid droplets is seen in the cytoplasm of SU1498-treated U87 cells.
相关产品:Covalent Screening Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | Protein Tyrosine Kinase Compound Library | Anti-Cancer Compound Library | Covalent Screening Library | Differentiation Inducing Compound Library | Reprogramming Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Bevacizumab | Sunitinib | Semaxinib | SU 5402 | PD173074 | 5Z-7-Oxozeaenol | Cediranib | SAR131675 | Gandotinib | GW806742X | Tanshi IIA | PF-03814735 | Vatalanib dihydrochloride | CP-547632 | AST 487 | Tyrphostin A9 | Ki20227 | Motesanib | SU14813 | Ramucirumab | MAZ51 | PP121 | Ki8751 | ZM 306416 | ZM323881 hydrochloride | SU5408
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