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Ansofaxine hydrochloride

CAS No. : 916918-84-8

MCE 站：Ansofaxine hydrochloride

产品活性：Ansofaxine hydrochloride (LY03005; LPM570065) 是三重重吸收抑制剂; 抑制血清素，多巴胺和去甲肾上腺素的 IC₅₀ 值分别为723，491 和 763 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：5-HT Receptor  |  Dopamine Receptor

In Vivo: Ansofaxine rapidly penetrates the rat striatum, converts into desvenlafaxine and exhibits larger total exposure compared with the administration of desvenlafaxine. Acute and chronic administration of oral suspension of ansofaxine increases the 5-HT, dopamine and norepinephrine levels more than the relative administration of desvenlafaxine. Unlike desvenlafaxine, acute administration of an intravenous ansofaxine solution does not induce the undesirable 90% decrease in extracellular 5-HT levels. The acute administration of ansofaxine shows a capped increase in extracellular 5-HT levels when combined with WAY-100635. Acute and chronic administration of ansofaxine reduces the immobility time more than the relative administration of desvenlafaxine.

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