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YM-46303

CAS No. : 171722-81-9

MCE 站：YM-46303

产品活性：YM-46303是一种毒蕈碱受体拮抗剂，对 M1 和 M3 受体表现出的亲和力，对M3受体的选择性较M2受体高。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：mAChR

In Vivo: YM-46303 shows approximately ten times higher inhibitory activity on bladder pressure in reflexly-evoked rhythmic contraction, and about 5-fold greater selectivity for urinary bladder contraction against salivary secretion in rats compared to oxybutynin. Further evaluation of antimuscarinic effects on bradycardia and pressor in pithed rats, and on tremor in mice, show that YM-46303 can be useful for the treatment of urinary urge incontinence as a bladder-selective M3 antagonist with potent activities and fewer side effects. YM-46303 shows in vivo selective inhibitory activities on bladder pressure in reflexly-evoked rhythmic contraction against oxotremorine-induced salivary secretion. In addition, YM-46303 has potent activity in a guinea pig model of methacholine-induced bronchospasm on intravenous administration.

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