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Dicire
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Dicire
CAS No. : 41020-79-5
MCE 站:Dicire
产品活性:Dicire (SC26304) 抑制醛固酮对尿 K+:Na+ 比例的调节作用,也抑制 [3H] 醛固酮与肾细胞质和核受体结合作用。
研究领域:Metabolic Enzyme/Protease
作用靶点:Mineralocorticoid Receptor
In Vivo: Cytoplasmic binding of [3H]Aldosterone and [3H]Dicire is similar in magnitude and involves the same set of sites. Under three sets of conditions-(i) in the intact rat, (ii) in kidney slices, and (iii) in reconstitution studies (mixing prelabeled cytoplasm with either purified renal nuclei or chromatin), [3H]Dicire does not yield specific nuclear complexes in contrast to the reproducible generation of these complexes with [3H]Aldosterone. In glycerol density gradients, cytoplasmic [3H]Aldosterone receptor complexes sediment at 8.5 S and 4 S in low concentrations of salt and at 4.5 S in high concentrations of salt. Cytoplasmic [3H]Dicire receptor complexes sediment at 3 S in low concentrations of salt and 4 S in high concentrations of salt. These results are discussed in terms of an allosteric model of the receptor system. Administration of Dicire (SC-26304) alone in doses of 3-600 μg/100 g of body weight has no effect on urinary Na+:creatinine or K+:creatinine ratios. These results are expressed as urinary K+:Na+ ratios. Aldosterone (0.3 μg/100 g of body weight) increases the K+:Na+ ratio 5-fold. This increase is significantly inhibited by 180 μg/100 g of body weight of Dicire and completely inhibit by 600 μg/100 g of body weight. To correlate inhibitory action and receptor occupancy, the same doses of Dicire are given to rats injected with 0.036 μg of [3H]Aldosterone. A dose of 180 μg of body weight reduces specific binding of Aldosterone in cytoplasmic and nuclear fractions to less than half of the control levels and 600 μg/100 g of body weight eliminated specific binding. The dose of Aldosterone used in the physiological studies is about eight times that used in the binding studies, but both doses are well below saturating amounts.
相关产品:Spironolactone | Eplere | Vamorolone | Deoxycorticosterone acetate | Fludrocortisone acetate | Canre | 18-Oxocortisol | Canrenoate potassium
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热门标签:SC26304