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Aranidipine

CAS No. : 86780-90-7

MCE 站：Aranidipine

产品活性：Aranidipine (MPC1304) 是一种钙离子 (Ca²⁺) 通道拮抗剂，具有强大而持久的抗高血压作用。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：Calcium Channel

In Vivo: Aranidipine (MPC-1304) is a new Ca²⁺ channel antagonist in spontaneously hypertensive rats. Following oral administration of Aranidipine at doses of 3 and 10 mg/kg to spontaneously hypertensive rats (SHR), there are significant decreases in B_max values for specific [³H](+)-PN 200-110 binding to myocardial membranes compared to the control values. The B_max values at 1 h (3 mg/kg), 1 and 6 h (10 mg/kg) are significantly decreased (47.7, 48.9 and 25.8%, respectively) compared to the control values. The effect is greatest at 1 h and decreases with time. The B_max values at 6 h (3 mg/kg) and 12 or 24 h (10 mg/kg) after the oral administration of Aranidipine are not significantly different from the control values, suggesting the disappearance of the effect of Aranidipine. The K_d values for myocardial [³H](+)-PN 200-110 binding are unaltered by oral administration of Aranidipine.

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